From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder - HHM

Open Access Repository for Health care Articles and Medical Researches

Post Top Ad

Your Ad Spot

Thursday, 28 September 2017

From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder

Authors: Bangshan Liu, Jin Liu, Mi Wang, Yan Zhang and Lingjiang Li


The serotonin (5-HT) hypothesis of depression has played an important role in the history of psychiatry, yet it has also been criticized for the delayed onset and inadequate efficacy of selective serotonin reuptake inhibitors (SSRIs).

 With evolvement of neuroscience, the neuroplasticity hypothesis of major depressive disorder (MDD) has been proposed and may provide a better framework for clarification the pathogenesis of MDD and antidepressant efficacy.

 In this article, we first summarized the evidence challenging the monoamine hypothesis and proposed that the antidepressant efficacy of SSRIs is not derived from elevated monoamine (5-HT, noradrenaline (NE), or dopamine (DA)) concentration or monoamine neurotransmission.

Second, we reviewed the role of stress in the pathogenesis of MDD and gave a brief introduction to the neuroplasticity hypothesis of MDD. Third, we explored the possible mechanisms underlying the antidepressant efficacy of typical antidepressants in the context of neuroplasticity theory.

Fourth, we tried to provide an explanatory framework for the significant difference in onset of efficacy between typical antidepressants and ketamine. Finally, we provided a brief summarization about this review article and some perspectives for future studies.

READ FULL ARTICLE AT JOURNAL WEBSITE (FREE ACCESS)